Extended Data Fig. 6: Comparison of VH1-69 antibody binding to Delta variant and wild-type spikes with or without x3 disulfide. | Nature Microbiology

Extended Data Fig. 6: Comparison of VH1-69 antibody binding to Delta variant and wild-type spikes with or without x3 disulfide.

From: SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope

Extended Data Fig. 6

a, VH1-69 antibody R1-32; R1-32 related VH1-69 antibodies b, FC08, c, 52; selected class 2 VH1-69 antibodies d, LY-CoV555, e, BG1-24, f, DH1043, g, MW01, h, MW05 were immobilized onto Protein A biosensors. Bindings of antibodies to unstabilized native (S-R) (ref. 8) and x3 disulfide stabilized RBD ‘down’ (S-R/x3) spikes (ref. 42) were compared to the corresponding Delta variant spikes (S-R/Delta, S-R/x3/Delta). Kinetic parameters are summarized in Supplementary Table 7.

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