Extended Data Fig. 4: Antigenic map of major variants of SARS-CoV-2 and animal sarbecoviruses.
From: SARS-CoV-2 Omicron variant emerged under immune selection
Antigenic cartography was generated by the neutralization titer 50% (NT50) of 16 sarbecoviruses (color circles) from a, all serum panels examined (n = 394, uncolored squares), b, serum from SARS-vaccinated (n = 11, uncolored squares). The x and y axes represented the antigenic distance, with the space of the grey grid lines showing 1 Antigenic Unit (2-fold dilution in titer).
