Extended Data Fig. 2: Maps of sMMO gene clusters in known methanotrophs and selected members of the order Mycobacteriales.
From: Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem
(a) Gene clusters encoding sMMO in Methylosinu strichosporium OB3b, Methylococcus capsulatus Bath, which are known methanotrophs, and Candidatus M. methanotrophicum from this study. Abbreviations: hyp, gene encoding a hypothetical protein; B, mmoB; D, mmoD; Z, mmoZ; hyd, hydrogenase gene cluster; empty arrow, unknown ORF; r, hypothetical transcriptional regulator; PEP-ck, gene encoding phosphoenolpyruvate carboxykinase; SS, signal sensor of a two-component regulatory system; RR, response regulator of a two-component regulatory system. Each structural mmo gene is shown in distinct color, regulatory mmoR and groEL homologue mmoG genes are in red and orange, respectively. Candidatus M. methanotrophicum does not have mmoG in close proximity, but does have groEL genes elsewhere (see Extended Data Fig. 3). (b) Gene maps of genomic regions containing one or more of the mmoRXYBDCZ genes. The maps are shown for the species in Cluster 1 of the phylogenetic tree shown in Supplementary Fig. 4. Note that, in this figure, the direction of the arrows does not reflect the direction of gene transcription.
