Table 1 Summary of Cas13a-mediated phage genome editing

Edit name	Phage	Edited locus	Edit style and scope	Survivors detected?	Plaques screened	Mutant success rate (%)
T4∆soc	T4	soc	Deletion	Yes	9	100
T7∆gp1.7	T7	gp1.7	Deletion	Yes	9	100
EdH4∆gp004	EdH4	gp004	Deletion	Yes	9	100
EdH4∆gp214	EdH4	gp214	Deletion	Yes	9	100
T4wtGT7	T4	gp52.1-rIIB	Large deletion	Yes	9	100
soc-C	T4	soc	SNP (1)	No	N/A	N/A
soc-S	T4	soc	SNP (3)	No	N/A	N/A
soc-F	T4	soc	SNP (11)	Yes	9	100
dnap-C	T4	dnap	SNP (3)	Yes	9	100
dnap-S	T4	dnap	SNP (5)	Yes	9	100
dnap-F	T4	dnap	SNP (9)	Yes	9	100

Following specific editing experiments, no plaques were detected. Thus, screening plaques and calculating efficiency were not applicable (N/A).

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