Extended Data Fig. 2: The identified natural compounds inhibit infection of SARS-CoV-2 Delta and Omicron variants.
From: Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2
(a) Schematic showing the experimental design, see methods for details.(b,c) Quantitative analysis of viral titer by plaque assays (B) and viral RNA genome copies by qRT-PCR (C) on Vero E6 cells treated with drugs at 1 𝜇M. qRT-PCR was performed with primers targeting the nucleocapsid gene (N) of SARS-CoV-2, normalized to internal control HRT1. Green bars indicate results of the Delta variant, red bars indicate results of the Omicron variant. The data are shown as mean ± s.d. (n = 3). P value, two-sided non-paired t-test between compound- and DMSO-treated groups. **P < 0.01. ***P < 0.001. Exact P values: (B) starting from bruceine A for Delta: 0.00048, 0.00048, 0.00034, 0.00034. (C) starting from bruceine A for Delta: 0.00052, 0.00052, 0.0022, 0.0021.
