Fig. 1: The subcellular protein atlas of Trypanosoma brucei.
From: Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
a, The position of T. brucei in a simplified phylogeny of eukaryotic life, redrawn from Burki et al.100. The human and yeast icons are used throughout to indicate when a protein has an orthologue in these species. TSAR, Telonemia, Stramenopiles, Alveolata and Rhizaria. b, The structure of the T. brucei cell. Each labelled organelle/structure is distinguishable by light microscopy. Further structures associated with cell division are also distinguishable. Organelles unique to, or with notable elaborations in, the T. brucei lineage are shown in bold. c, Number of proteins annotated with each annotation term, giving a representation of the relative complexity of each T. brucei organelle. Transparent circles represent grouping of annotation terms in an ontology hierarchy. This organelle colour key is used throughout all figures. d, Examples of previously uncharacterized proteins localizing to different organelles either unique to or with notable elaborations in the T. brucei lineage, representative of the quality of microscopy data. T. brucei TREU927 gene IDs (minus the Tb927. prefix) are shown in the top left and the terminus of endogenous tagging in the bottom left.
