Fig. 2: Mapping eukaryote-wide conserved and parasite-specific features.
From: Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
a, Presence of orthologues of T. brucei proteins, grouped by organelle, across eukaryotic life. Pies represent the proportion of proteins with a reciprocal best BLAST (RBB, black) or not an RBB but at least one orthogroup member (grey) in each species. Extended version in Extended Data Fig. 3. b, Conservation of localization for proteins with an orthologue in humans or yeast (both budding and fission), broken down by organelle, with human or yeast annotations mapped to our most similar T. brucei term. Some localizations cannot match (for example, flagellum) as yeast cells lack the structure and cilia were not annotated in human cells. c, Euler diagrams showing the degree of agreement of localization of the proteins with a single orthologue in human, yeast and T. brucei cells or, for the basal body, just humans and T. brucei.
