Extended Data Fig. 4: CD8⁺ T cell depletion in SIV-infected Rhesus macaques does not increase CD4⁺ T cell proliferation.

In Figures a–c: Blue triangle indicates SIVmac239M infection, red triangle indicates CD8⁺ T cell depletion prior to infection, orange triangle indicates CD8⁺ T cell depletion prior to ART initiation. Grey box represents ART. a. CD4⁺ T cell count in peripheral blood in Pre-infection CD8⁺ depletion group (n = 8 macaques, magenta line), Pre-ART CD8⁺ depletion group (n = 8 macaques, teal line), and control group (n = 5 macaques, black line). Data are mean ± s.e.m. Kruskal Wallis test was used to compare the value between the groups. b,c. Lines on each graph represents individual animals in each study group and indicated in key under each column of graphs. Longitudinal flow cytometry analysis after CD8⁺ T cell depletion Pre-infection CD8⁺ depletion group (n = 8 macaques, magenta line), Pre-ART CD8⁺ depletion group (n = 8 macaques, teal line), and control group (n = 5 macaques, black line). Percentage of bulk CD4⁺ T cells that express Ki-67 in peripheral blood (b) and lymph nodes (c). * p value less than 0.05; ** p value less than 0.01.