Extended Data Fig. 6: Longitudinal SIV plasma viremia and barcode analysis.

For Figures a, b: SIV plasma viral load in the three experimental groups. Limit of detection is 60 copies of SIV RNA per mL of plasma (horizontal dashed line). Blue triangle indicates SIVmac239M infection, red triangle indicates CD8⁺ T cell depletion prior to infection, orange triangle indicates CD8⁺ T cell depletion prior to ART initiation. Grey box represents ART. a. SIV plasma viremia during the first 120 days p.i in the three experimental groups. Lines on each graph represents individual animals in each study group and indicated in key under each column of graphs. For Figures b, c: magenta squares/lines represent the Pre-Infection group (n = 8 macaques), teal triangles/lines represent the Pre-ART group (n = 8 macaques), black circles/lines represent the control group (n = 5 macaques). b. SIV plasma viremia until day 210 p.i in the three experimental groups. Data are mean ± s.e.m. Kruskal-Wallis tests were used to compare values between the groups. c. Analysis of the barcode diversity at day 14 post infection (at time of ART initiation). Data are mean ± SD. Kruskal-Wallis test was used to compare values between the groups. * p value less than 0.05; ** p value less than 0.01; *** p value less than 0.001; **** p value less than 0.0001.