Fig. 4: Species-specific activity of ARGs across bacterial species.

a, Heat map showing substantial variation in the resistance levels provided by the 13 resistance-conferring DNA fragments in the four host species. Colour code quantifies MIC fold changes. White colour means no change in resistance level, using a twofold change in MIC as a cut-off. Data are available in Supplementary Table 9. b, Adjusted Jaccard similarity coefficients that represent the overlaps of functional ARG sets between pairs of host species after controlling for measurement noise (see Methods and Extended Data Fig. 8). Numbers in brackets represent 95% confidence intervals (Methods).