Extended Data Fig. 1: Intestinal pyogranulomas form upon oral Yersinia infection.

(a) Flow cytometry plots displaying the gating strategy employed to identify eosinophils, dendritic cells, B cells and T cells in small-intestinal tissue at day 5 post-Yp infection. Representative of four independent experiments. (b) Frequency and total number of eosinophils, dendritic cells, B cells, CD4⁺ T cells and CD8⁺ T cells in small-intestinal tissue at day 5 post Yp-infection. Each data point represents one mouse (n = 15-20). Lines represent median. Pooled from four independent experiments. Wilcoxon test (two-tailed) was performed for paired analyses (PG- vs PG + ). Mann-Whitney U test (two-tailed) was performed for all remaining statistical analyses. * (p < 0.05), ** (p < 0.01), *** (p < 0.001), **** (p < 0.0001), NS (not significant, p > 0.05).