Extended Data Fig. 3: Immune cell responses in blood. | Nature Microbiology

Extended Data Fig. 3: Immune cell responses in blood.

From: Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

Extended Data Fig. 3

(a) Two-dimensional projections of single-cell transcriptomes using UMAP of blood cells from prime-boost experiment. Cells are colored by cell types as annotated based on known marker genes. (b, d) Numbers of cellular components per ml blood for the prime-boost experiment. (c) Percentage of blood cellular components for the prime-boost experiment. (b – d) One-way ANOVA and Dunnett’s multiple comparisons test against mock-mock group per cell type are shown. Mean ± SEM, symbols represent individual hamster. nsCPD9 + sCPD9 = 3, nmRNA + sCPD9 = 3, nmRNA + mRNA = 3, nAd2 + Ad2 = 3, nmock + mock = 4 individual hamsters as symbols. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.

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