Fig. 1: Alterations in gut bacterial species in AN cases compared to healthy controls, and associations with eating disorder scores.
From: The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
a,b Box plot (line, median; box, interquartile range (IQR); whiskers, 1.5× IQR) of β-diversity of AN (n = 77) and HC (n = 70) gut microbiota (a) and of two AN subtypes (AN-RS n = 56, AN-BP n = 21) and HC gut microbiota (b) at bacterial species level (Canberra distance). Statistical significance of differences between two groups was determined by Wilcoxon rank-sum test (two-sided). c, Significantly contrasted bacterial species between AN and HC. Differences in abundance were detected using the metadeconfoundR pipeline where covariates including age, BMI, smoking and multiple drug intake were corrected. Cliff’s delta values give estimates of effect size. For each contrasted MSP, prevalence in the whole cohort, HC, AN, and Padj are given next to the MSP annotation. d, Heat map showing that gut bacterial species are linked to eating disorder scores in AN cases, using a linear regression model where age, BMI, smoking and multiple drug intake were defined as covariates and adjusted for. Variables in specific eating disorder scale are marked in blue, and general psychological scale is marked in red. Right panel to the heat map indicates the direction of each variable. For each MSP, prevalence in AN is given next to the MSP annotation. +, Padj < 0.05 by Benjamini-Hochberg method (see for exact P values).
