Extended Data Fig. 10: Effects of FMT from AN and controls to female GF mouse littermates.
From: The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
a, Body weight change and fat percentage of germ-free (GF) mouse littermates (n = 21) fed with ad libitum chow diet and transplanted with microbiota from anorexia patients. b, Body weight change compared to the body weight at day 0 after energy-restricted diet for three independent experiments (n = 8, 6, and 6 for independent batches, respectively). Data are expressed as mean ± s.e.m.(a,b). Significance was calculated by two-way analysis of variance (ANOVA), followed by Benjamini-Hochberg post hoc test. c, Serum metabolome profile in human donors and GF mouse recipients fed with 30% energy-restricted diet. Data were expressed as the log2-transformed fold changes (log2FC) between AN and control groups. Positive log2FC values indicate AN-enriched metabolites, while negative log2FC values indicate HC-enriched metabolites. Serum metabolites that were persistently changed between AN and HC groups in human donors and GF mouse recipients were marked with blue bars. CA, cholic acid; DCA, deoxycholic acid; FFA, free fatty acid; w/a-MCA, ω/α-muricholic acid; HDCA, hyodeoxycholic acid; TaMCA, taurine-α-muricholic acid; CDCA, chenodeoxycholic acid; LCA, lithocholic acid; UDCA, ursodeoxycholic acid; G, glycine-conjugated bile acids; T, taurine-conjugated bile acids. d, Heat map on the left panel showing the correlation between ASVs and quantified genes in hypothalamus or subcutaneous white adipose tissue. Taxonomic information of ASVs is given on the right panel. +, p < 0.05 corrected by Benjamini-Hochberg method (see Source Data for exact p values).
