Extended Data Fig. 2: Taxonomic differences at phylum, family and genus level and differences in enterotypes in cases with AN compared with healthy women.
From: The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
a,b,e Box plot (line, median; box, interquartile range (IQR); whiskers, 1.5× IQR) of comparison between AN (gold, n = 77) and HC (blue, n = 70) of relative abundance of the 12 bacterial phyla detected in at least 10% of individuals (a), the 20 most abundant bacterial families (b), and the top 30 genera (e). Features are sorted by decreasing mean abundance. Zero values are set to 1e-10. Features colored in blue are enriched in HC group, and gold are enriched in AN group. Significance was determined by two-sided Wilcoxon rank-sum test, followed by drug-deconfounding and multiple testing correction by Benjamini-Hochberg method on all features (a,b,and e, see Source Data for exact p values). c,f, Absolute values of Cliff’s Delta effect size of families (c) and genera (f) contrasted between AN and HC after drug-deconfounding (adjusted p-value ≤ 0.1). Gold barplots indicate features more abundant in AN; blue barplots indicate features more abundant in HC (c,f). d,g, Box plot (line, median; box, IQR; whiskers, 1.5× IQR) showing β-diversity (Canberra distance) of gut bacteriome at genus level (d) and richness of Metagenomic Species Pan-genomes (MSPs) (g) between AN (gold, n = 77) and HC (blue, n = 70). Significance was determined by two-sided Wilcoxon rank-sum test (d,g). h, Upper panel demonstrates enterotype prevalence in AN (n = 77) and HC (n = 70), lower panel shows enterotype prevalence in HC and AN patients split into AN-RS (n = 56) and AN-BP (n = 21) groups.
