Extended Data Fig. 4: The function of Shisa9 in microglia and astrocytes during HSV-1 infection.
From: Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice
(a–d) Immunofluorescence (a and c) and quantitation (b and d) for IFNβ, IL-6 or HSV-1 (red) on Iba1+ microglia or GFAP+ astrocytes (green) to identify the source of indicated cytokines in the brains of WT and Shisa9−/− mice at day 3 or day 18 after intracranial infection with HSV-1(1 × 102 PFU). Scale bars (a and c), 100 μm. In (b and d), all error bars, mean values ± SD of 8 mice. P-values were determined by unpaired two-tailed Student’s t test.
