Extended Data Fig. 1: Statin-modulated microbiota mediates chemopreventive effects.

a, Scheme for the experiment design. Apc^Min mice were administered 2% Tween 80 (vehicle control), or atorvastatin (20 mg/kg). b, Body weight of Apc^Min mice receiving vehicle control or atorvastatin was recorded (n = 10 mice per group). c, Representative macroscopic images of colons. (d-h) d, Scheme for the experiment design. Apc^Min mice were administered 2% Tween 80 (vehicle control), or lovastatin (20 mg/kg) (n = 10 mice per group). e, Representative macroscopic images of colons. f, Colon tumor number under different treatments. g, Colon tumor volume under different treatments. h, Representative H&E staining of colons under different treatments. i-m, i, Scheme for the experiment design. Apc^Min mice were administered 10% DMSO (vehicle control), or fenofibrate (100 mg/kg) (n = 10 mice per group). j, Representative macroscopic images of colons. k, Colon tumor number under different treatments. l, Colon tumor volume under different treatments. m, Representative H&E staining of colons under different treatments. n, Scheme for the experiment design. Microbiota-depleted Apc^Min mice were administered vehicle control, or atorvastatin. o, Representative macroscopic images of colons. p, Scheme for the experiment design. Microbiota-depleted Apc^Min mice were administered feces from mice receiving vehicle control or atorvastatin (Ator). q, Representative macroscopic images of colons. Data with error bars represent the mean ± s.d. Data were analyzed by two-tailed Welch’s t test (b, f, g), and two-tailed unpaired Student’s t test (b, k, l).