Table 1 Changes in gene expression and relative protein abundance in the S. iranensis ΔbldA mutant compared with the WT

Gene name	Gene ID	mRNA steady-state level (log₂(ΔbldA/WT fold change))	Protein abundance (log₂(ΔbldA/WT fold change)
azl5	SIRAN1022	−6,91	−1,54
azl4	SIRAN1023	−7,28	−4,58
azlA	SIRAN1024	−7,54	−3,69
azlH	SIRAN1025	−7,52	−4,43
azlG1	SIRAN1026	−7,32	−6,88
azlG2	SIRAN1027		−4,34
azlF	SIRAN1028		−5,04
azlE1	SIRAN1029	−7,60	−2,90
azlE2	SIRAN1030		−4,51
azlE3	SIRAN1031		−3,16
azlD1	SIRAN1032		−3,04
azlD2	SIRAN1034		−2,59
azlD3	SIRAN1036		−4,41
azlD4	SIRAN1037		−4,69
azlC1	SIRAN1038		−2,85
azlC2	SIRAN1039		−2,73
azlB1	SIRAN1040		−2,88
azlB2	SIRAN1042		−4,00
azlB3	SIRAN1043		−3,60

Steady-state mRNA levels and relative protein abundance of core biosynthetic genes/proteins of the azalomycin F BGC. Data are depicted as the log₂-transformed fold change of the transcripts-per-kilobase-million values and protein abundance measured in the ΔbldA mutant compared with the WT. No value for the log₂-transformed fold change for the mRNA steady-state level indicates that no detectable transcripts mapped to these genes.

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