Extended Data Fig. 10: The MBOAT proteins in non-Dlt pathway cell envelope acylation systems have additional C-terminal helices that allow the C-terminal motif of these proteins to nestle into the active site.
From: Mechanism of d-alanine transfer to teichoic acids shows how bacteria acylate cell envelope polymers
Alignments of predicted structures of MBOAT proteins from bacterial cell envelope polymer acetylation systems (and a system of unknown function in archaea) with the predicted structure of the DltBX complex show that the non-DltB MBOAT proteins likely share a similar architecture to DltB but with a C-terminal extension of several additional helices. All of the predicted structures here were generated using the ColabFold implementation of AlphaFold2 and aligned using the PyMOL ‘super’ command.
