The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential.
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References
European Food Safety Authority et al. EFSA J. 21, e07917 (2023).
Aguero, M. et al. Euro. Surveill. https://doi.org/10.2807/1560-7917.ES.2023.28.3.2300001 (2023).
Puryear, W. et al. Emerg. Infect. Dis. 29, 786–791 (2023).
H5N1 Highly Pathogenic Avian Influenza in Poultry and Wild Birds: Winter of 2021/2022 with Focus on Mass Mortality of Wild Birds in UK and Israel (WOAH, 2022).
Long, J. S. et al. Nat. Rev. Microbiol. 17, 67–81 (2019).
Avian Influenza Weekly Update Number 906 (WHO, 2023); https://go.nature.com/3sbxXof
Wang, M., Fu, C. X. & Zheng, B. J. N. Engl. J. Med. 360, 2583–2584 (2009).
Sandbulte, M. R. et al. PLoS Med. 4, e59 (2007).
Imai, M. et al. Nature 486, 420–428 (2012).
Stevens, J. et al. Science 312, 404–410 (2006).
Haller, O. et al. Trends Microbiol. 23, 154–163 (2015).
Chen, Y. et al. Science 373, 918–922 (2021).
Manz, B. et al. PLoS Pathog. 9, e1003279 (2013).
Gotz, V. et al. Sci. Rep. 6, 23138 (2016).
Graaf, A. et al. Emerg. Infect. Dis. 29, 1492–1495 (2023).
Acknowledgements
The work was funded by a grant from the European Research Council to M.S. (no. 882631—Bat Flu); grants from the Deutsche Forschungsgemeinschaft to M.S. (SCHW 632/16-1) and M.B. (BE 5187/4-2); the EU Horizon 2020 program grant agreement VEO (no. 874735) to M.B.; and the medical faculty at the University of Freiburg through the Hans A. Krebs Medical Scientist Programme to K.C.
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Ciminski, K., Chase, G., Schwemmle, M. et al. Advocating a watch-and-prepare approach with avian influenza. Nat Microbiol 8, 1603–1605 (2023). https://doi.org/10.1038/s41564-023-01457-0
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DOI: https://doi.org/10.1038/s41564-023-01457-0
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