Fig. 1: Prevalence of K13 and key drug-resistance mutations in Ethiopia.
From: Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia
a, Spatial distribution of K13 622I mutation at the district (pie charts) and regional (bar plot) levels. Colours indicate mutation status and pie chart size is proportional to sample size per district. The black triangle indicates the location where K13 622I mutation was reported previously. b, Prevalence of non-synonymous mutations across the K13 gene, coloured according to WHO ACT resistance marker category. K13 gene annotation shows 1–350 amino-acid residues in the poorly conserved Plasmodium-specific region and 350–726 residues in the beta propeller domain where validated resistance mutations are located. c, Prevalence of mutations across four key P. falciparum genes (colours) associated with commonly used antimalarial drugs.
