Extended Data Fig. 6: Bach1-deficient mice exhibit increased expression of antioxidant genes associated with iron and glutathione metabolism.
From: BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
Volcano plot of the differentially expressed genes between Bach1-/- and WT AM (cluster 15), neutrophil (clusters 4, 5 and 17) and macrophage/monocyte populations (cluster 1, 2, 6, 8, 9, 16, 18) are shown (n = 5, each group; samples pooled from one experiment). Vertical and horizontal red lines indicate log fold change ≥ 0.5 and p-ad value < 0.05 respectively. Positive-fold change indicates higher expression in Bach1-/- relative to WT. Statistical significance in was calculated with the Wilcoxon Rank-Sum test.
