Fig. 1: Overview of hypothesized mechanism of positive selection for resistance to Lassa fever mediated by LARGE1. | Nature Microbiology

Fig. 1: Overview of hypothesized mechanism of positive selection for resistance to Lassa fever mediated by LARGE1.

From: Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever

Fig. 1

a, Statistical evidence for positive selection at the LARGE1 locus, adapted from Andersen et al.17. The y axis shows the composite likelihood score which integrates evidence of positive selection based on population differentiation (fixation index), long haplotype (integrated haplotype score, delta integrated haplotype score, cross-population extended haplotype homozygosity) and derived allele frequency. On the figure, p refers to the short arm of the chromosome, while q refers to the long arm. See Andersen et al.17 for details. b, Hypothesized mechanism by which decreased activity of LARGE1 increases resistance to LASV infection and Lassa fever.

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