Fig. 2: GWAS of Lassa fever clinical outcome. | Nature Microbiology

Fig. 2: GWAS of Lassa fever clinical outcome.

From: Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever

Fig. 2

a, Immunoglobulin G seropositivity rate in Nigerian (NG) and Sierra Leonean (SL) controls stratified by age. Error bars represent 95% bootstrap confidence intervals. NG: N of 24 in 0–19 years, 424 in 20–39 years, 269 in 40–59 years and 34 in 60+ years. SL: N of 33 in 0–19 years, 282 in 20–39 years, 191 in 40–59 years and 83 in 60+ years. b–d, Manhattan plots showing the −log P value for each genomic variant for the Lassa fever outcome association for Nigeria (b), Sierra Leone (c) and meta-analysis (d). P values for b and c are based on SAIGE, while P values for d are derived from meta-analysis (METAL) of P values shown in b and c.

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