Extended Data Fig. 5: Inhibition of P132H Mpro by RAY1216 and PF-07321332. | Nature Microbiology

Extended Data Fig. 5: Inhibition of P132H Mpro by RAY1216 and PF-07321332.

From: Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir

Extended Data Fig. 5

a, RAY1216 inhibition progress curves (dots) are overlaid with best-fit model curves; the residuals of the fits are shown. b, Plots of instantaneous reaction rates for the progress curves in panel a. c, PF-07321332 inhibition progress curves (dots) are overlaid with best-fit model curves; the residuals of the fits are shown. d, Plots of instantaneous reaction rates for the progress curves in panel c. See Enzyme kinetics section of Supplementary Information for details of data analysis procedures.

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