Extended Data Fig. 8: Validating the effects of P. copri colonization on postnatal weight gain and host metabolism in gnotobiotic dam-pup dyads. | Nature Microbiology

Extended Data Fig. 8: Validating the effects of P. copri colonization on postnatal weight gain and host metabolism in gnotobiotic dam-pup dyads.

From: Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

Extended Data Fig. 8

(a) Study design (n = 4 dams and 18 and 19 offspring for arms 1 and 2, respectively). (b) Body weights of the offspring of dams, normalized to postnatal day 23 [linear mixed effects model (see Methods)]. (c-e) Targeted mass spectrometric analysis of jejunal citrulline (panel c) and acylcarnitine levels (panel d), plus colonic acylcarnitine levels (panel e). Exact P-values for jejunal C3 and jejunal C18:1 (panel d) are 1x10-5 and 7x10-4, respectively. Exact P-values for colonic C4/Ci4, C5, C16, and C18:1 (panel e) are 3x10-6, 2x10-6, 3x10-4, and 7x10-4, respectively. (f) Plasma levels of non-esterified fatty acids. Each dot represents a single animal. Mean values ± SD are shown for panels b-f. P-values were calculated from the linear mixed effect model (panel b) or two-sided Mann-Whitney U test (panels c-f). N.S., P-value > 0.05.

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