Extended Data Fig. 2: Single-organoid proteomic analysis (associated to Supplementary Table 1 and 2). | Nature Microbiology

Extended Data Fig. 2: Single-organoid proteomic analysis (associated to Supplementary Table 1 and 2).

From: Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis

Extended Data Fig. 2

Cerebral organoids differentiated for 45 days were mock-infected or infected for 10 days with SARS-CoV-2 at 105 pfu or 106 pfu per organoid and processed for single-organoid differential proteomics comparing infected organoids to their non-infected counterparts using nanoLC-MS/MS. (a) Protein network analysis using GSEA of the upregulated cellular component upon infection of cerebral organoids. (b–e) Patterns of differential post-translational modifications (PTM) in mock-infected (B), and SARS-CoV-2-infected samples at 105 pfu (C) or 106 pfu (D) were obtained by averaging relative quantifications.

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