Extended Data Table 2 Pharmacokinetic (PK) and plasma binding (PB) parameters of fluorofolin

From: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

  1. PK values were calculated from three mice given 200 mg/kg fluorofolin PO. Plasma was collected at 0.083, 0.25, 0.5, 1, 2, 4, 8, and 24 hours post treatment for LC/MS-MS analysis. PB values were determined from incubation of fluorofolin with purified mouse plasma over 6 hours. PB parameters were calculated from LC/MS-MS measurements of duplicate samples.
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