Extended Data Table 2 Affinity data

From: Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Averaged Kinetic Parameters

 

ka1 (104M−1s−1)

kd1 (10−3s−1)

kD1 (e-9)

Bmax1 (Hz)

LDL

25.5

1.12

3

70

CCHFV Gc

1.3

0.059

3.3

64

Gc + Gn

2.1

0.00867

0.272 (272pM)

7

  1. The QCM data were assessed and analysed using the Evaluation (Attana AB) and TraceDrawer software (Ridgeview Instruments), employing 1:1 or 1:2 binding models to calculate kinetic parameters, including rate constants (ka, kd), dissociation equilibrium constant (KD), and maximum binding capacity (Bmax).
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