Table 1 Antimicrobial activity assays (under standard conditions) of plectasin mutants (MIC in μg ml−1)

From: Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism

Drug/strain

S. simulans 22

Plectasin wt

0.78

I22D

>50

I22F

>50

I22K

>50

I22L

1.56

I22V

1.56

K23A

6.25

Y25F

1.56

Y25H

≤0.78

Y25I

6.25

Y25L

3.13

Y25V

6.25

K26A

3.13

K26R

≤0.78

Y29A

12.5

Y29F

1.56

Y29R

1.56

Y40R

>50

Y40F

1.56

Vancomycin

0.78

  1. See Supplementary Table 1 for additional activity assays.
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