Extended Data Fig. 4: Host gene expression comparing SLCLs between MS and HCs. | Nature Microbiology

Extended Data Fig. 4: Host gene expression comparing SLCLs between MS and HCs.

From: Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease

Extended Data Fig. 4

(a) Heat map analysis of RNA-seq showing top cellular genes that are upregulated (red) or downregulated (blue) in HC, SMS, and AMS SLCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL, n = 5,). (b) IPA showing top pathways that are activated (red) or inactivated (blue) in MS SLCLs compared to HC SLCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL, n = 5,). (c) Volcano plot highlighting differentially regulated host genes in MS SLCLs vs HC SLCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL n = 5). (d) IPA showing top regulators that are activated (red) or inactivated (blue) in MS SLCLs compared to HC LCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL n = 5,). Statistical analysis performed using DSeq2. All data points represent distinct samples.

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