Extended Data Fig. 5: Host gene expression comparing Active MS SLCLs to Non-Active SLCLs (SMS SLCLs + HC SLCLs). | Nature Microbiology

Extended Data Fig. 5: Host gene expression comparing Active MS SLCLs to Non-Active SLCLs (SMS SLCLs + HC SLCLs).

From: Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease

Extended Data Fig. 5

(a) Volcano plot comparing top differentially regulated genes in AMS SLCLs vs non-active SLCLs(HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL, n = 5) DSeq2 Wald Test. (b) Ingenuity pathway analysis showing top pathways that are activated (red) or inactivated (blue) in MS SLCLs compared to HC LCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL n = 5). (c) IPA showing top regulators that are activated (red) or inactivated (blue) in AMS SLCLs vs non-active SLCLs (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL, n = 5). (d) Gene expression (normalized counts) in AMS (red), SMS (green) and HC (blue) SLCLs for IL12B and ZMIZ1 (DESeq Wald test) (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL n = 5). Stattistical analysis performed using DSeq2 Wald Test. All data points represent distinct samples tested. Data for (d) are mean ± SD.

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