Extended Data Fig. 3: Host protein and gene expression in SLCLs compared to LCLs. | Nature Microbiology

Extended Data Fig. 3: Host protein and gene expression in SLCLs compared to LCLs.

From: Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease

Extended Data Fig. 3

(a) Flow cytometry analysis of CD20, Ki67, HLA Class I, and CD45 expression in SLCL HC, SMS, AMS, LCL (B95.8), LCL (Mutu-I), and BJAB. (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL n = 5, LCL n = 16). (b) Principal Component Analysis (PCA) of RNA-Seq comparing SLCLs (green) and LCLs(orange). (c) Volcano plot comparing host gene expression in LCLs vs SLCLs. (d) Gene expression (normalized counts) in LCLs (green) vs SLCLs (red) (DESeq Wald test) (HC SLCL, n = 4; SMS SLCL, n = 6; AMS SLCL, n = 5; LCL n = 15). All data points represent distinct samples. Stattistical analysis performed using DSeq2 Wald test. Data are mean ± SD.

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