Extended Data Fig. 10: Metabolic competition for dulcitol is a key factor for protection against S. Tm.
OMM12 mice were colonized with 5 × 108 CFUs of K. oxytoca MK01 sKO, sKOΔgatABC or left untreated four days before infection. At day 0 mice were orally infected with 5×105 CFUs of S. Tm and BWL and fecal colonization were monitored until day 6 p.i. Organs were sampled at day 6 p.i. (a) Resulting CFUs in the lumen and tissue of cecum and (b) colon. (c) Colon length at day 6 p.i. and (d) resulting CFUs in the lumen and tissue of the small intestine and (e) extra-intestinal organs including spleen, liver and MLN. (a-e) The mean and SEM of two independent experiments with n = 7 (PBS) or n = 8 (sKo/WT) mice per group are displayed. P values indicated represent Ordinary One-Way ANOVA with Dunn’s multiple comparisons test with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
