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Fungal pathogenesis

Body heat drives antifungal resistance

Nature Microbiology volume 9, pages 1638–1639 (2024)Cite this article

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Multi-drug resistance and virulence in Rhodosporidiobolus fluvialis, an emergent human fungal pathogen that causes fungaemia, is driven by body-temperature-induced elevated mutation rates.

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Fig. 1: Body temperature induces elevated mutation rate in the novel fungal pathogen R. fluvialis leading to increased virulence and pan-antifungal resistance.

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Authors and Affiliations

  1. Manchester Fungal Infection Group, Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

    Michael J. Bottery & David W. Denning

Authors
  1. Michael J. Bottery
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  2. David W. Denning
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Correspondence to David W. Denning.

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The authors declare no competing interests.

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Bottery, M.J., Denning, D.W. Body heat drives antifungal resistance. Nat Microbiol 9, 1638–1639 (2024). https://doi.org/10.1038/s41564-024-01738-2

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