Extended Data Fig. 2: Operational taxonomic unit level-based microbiota analysis of SPF-housed mice.
From: Gut microbial factors predict disease severity in a mouse model of multiple sclerosis
All samples were analysed together using the same analysis pipeline. Only operational taxonomic units (OTUs) that provided a mean relative abundance of > 0.01% in at least one group were included in the analyses. Intersection analysis to identify taxa, which are either present or absent only in Muc2−/− mice. Taxa were considered ‘present’ within a certain group, when group mean relative abundance of a given taxon was > 0.01%. Otherwise, taxa were considered ‘absent’ in the respective group. Left panels, intersection sizes of OTUs between the five groups. Three different intersection sizes are shown (‘Distinct’, ‘Intersect’, and ‘Union’), which are explained in the lower panels. Middle panel, Venn diagram highlighting the number of shared and distinct OTUs between the groups. Dark red, taxa only present in Muc2−/− mice; teal, taxa not present in Muc2−/− mice, but in all other mice; orange, core microbiome shared by mice of all five groups. List of OTUs belonging to these three groups provided on the right side.
