Extended Data Fig. 9: Bismuth enhances the activities of antibiotics ex vivo. | Nature Microbiology

Extended Data Fig. 9: Bismuth enhances the activities of antibiotics ex vivo.

From: Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis

Extended Data Fig. 9

a, Ex vivo bacteremia model for antibiotics, bismuth drugs, and their combined antimicrobial activity. 10 μL of serial decimal dilutions of each one of the combinations of antibiotics with/without bismuth drugs (32 μM) tested in blood were dropped. All the tests were performed in triplicate. b, The appearance of the blood infected with PAO1 after treatment with the indicated concentration of antibiotics alone or the combinations with bismuth for 24 h. Black color of the blood indicates hemolysis and therefore bacterial growth. Red color of the blood indicates the therapy controlled the infection. All the tests were performed in triplicate.

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