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Silencing the transcriptionally active HIV reservoir to improve treatment outcomes

Nature Microbiology volume 9, pages 2470–2472 (2024)Cite this article

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Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation. Supplementing antiretroviral therapy with transcriptional inhibitors could overcome this by silencing the transcriptionally active HIV reservoir.

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Fig. 1: Potential mechanisms of immune stimulation by the TAHR under ART.
Fig. 2: Nuclear targets to inhibit viral transcript production and export.

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Acknowledgements

This research was supported by NIAID award number UM1AI164559, co-funded by NHLBI, NIDA, NIMH, NINDS and NIDDK.

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Author notes

  1. These authors contributed equally: Julia Prigann, Rubens Tavora.

Authors and Affiliations

  1. Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA

    Julia Prigann, Robert L. Furler O’Brien, Ursula Schulze-Gahmen, Daniela Boehm, Nadia R. Roan & Melanie Ott

  2. Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Research Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA

    Rubens Tavora & Susana Valente

  3. The Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, USA

    Rubens Tavora & Susana Valente

  4. Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

    Robert L. Furler O’Brien & Douglas F. Nixon

  5. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

    Robert L. Furler O’Brien, Douglas F. Nixon & Lishomwa C. Ndhlovu

  6. Department of Urology, University of California San Francisco, San Francisco, CA, USA

    Nadia R. Roan

  7. Department of Medicine, University of California San Francisco, San Francisco, CA, USA

    Melanie Ott

Authors
  1. Julia Prigann
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  2. Rubens Tavora
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Corresponding authors

Correspondence to Lishomwa C. Ndhlovu, Susana Valente or Melanie Ott.

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The authors declare no competing interests.

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Prigann, J., Tavora, R., Furler O’Brien, R.L. et al. Silencing the transcriptionally active HIV reservoir to improve treatment outcomes. Nat Microbiol 9, 2470–2472 (2024). https://doi.org/10.1038/s41564-024-01816-5

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