Extended Data Fig. 8: Inter-Fab interaction between the two adjacent h1A6.2 and molecular dynamics simulation of CVA16 virion. | Nature Microbiology

Extended Data Fig. 8: Inter-Fab interaction between the two adjacent h1A6.2 and molecular dynamics simulation of CVA16 virion.

From: Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2

Extended Data Fig. 8

a, The models show two adjacent h1A6.2 Fabs (showed as carton with transparent surface representation) and the 2 protomers (showed as carton and color with components) consisting the 2-fold region of CVA16 empty particles. b, close-up view shows interaction details of the two h1A6.2 Fabs. Hydrogen bonds and salt-bridges are indicated as orange and green dashed lines, respectively. c, Root mean square deviation (RMSD) of backbone atoms of CVA16-M, CVA16-E and CVA16-E:h1A6.2 (with h1A6.2 omitted). d, Root mean square fluctuation (RMSF) of viral VP2 that involved in h1A6.2 binding during the last 20 ns of the MD simulation.

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