Fig. 1: Chuvirus EVEs in vertebrate genomes.
From: Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes
a, Bayesian phylogenetic tree of the RdRps of exogenous chuviruses and the EVEs found in teleost fish (in red). Some species have multiple integrations suggesting a close interaction with these viruses and recurrent integrations, or possibly a single integration event followed by intragenomic amplification. Note how the vertebrate-associated viruses form a monophyletic group, while the arthropod-associated ones are paraphyletic. The tree was rooted with Hubei myriapoda virus 8 (Myriaviridae) and Megalopteran chu-related virus 119 (MCrV, Crepuscoviridae) as outgroups. Tree inferred in MrBayes3 using the LG + F + I + G4 model and 4.74 M generations (relative burn-in = 25%). EVEs are shown in red. Pa., Paramormyrops; F., Fundulus; Po., Poecilia; A., Austrofundulus; O., Oryzias; ClV, chuvirus-like virus. b, CLANS network of the nucleoprotein of exogenous chuviruses, vertebrate chuvirus EVEs and the two outgroups mentioned above. Edges are drawn between nodes with a significance of P < 1 × 10−15. The vertebrate EVEs are well connected to the central network that includes vertebrate-associated chuviruses and a number of chuviruses from arthropods. Sg, Salarius guttatus; GrbSCV, Guangdong red-banded snake chuvirus-like virus. c, Syntenic arrangement of the most-proximal genes was used to establish orthology of three integrations. The minimum date of integrations in each species pair is based on the divergence of the host species in TimeTree. M., Monodelphis; G., Gracilinanus; V., Vombatus; Ph., Phascolarctos.
