Fig. 5: Hepacivirus EVE in the genomes of rodents from the subfamily Murinae.
From: Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes
a, Conserved domain annotation of the rodent hepacivirus ETH674/ETH/2012 (QLM02864.1) polyprotein. The region of homology to the EVEs is embedded within the ps-ssRNA domain. b, Comparison of the region of homology between rodent hepacivirus ETH674/ETH/2012 (top sequence) and the consensus sequence obtained from 21 murine genomes (middle sequence). Identical amino acids at a given position are highlighted in a red box (the two sequences are 75% pairwise identical at the amino acid level). The sequence logo at the bottom shows variation at the given position proportional to frequency (0–100%). c, Orthology across 6 representative species in 6 tribes (Murini, Praomyini, Apodemini, Arvicanthini, Hydromyini, Rattini) of the subfamily Murinae, together with a phylogeny of the group. Flanking genes were identified in the mouse (Mus musculus) assembly and used to annotate the region in the other assemblies. Red bars, internal stop codons; black rectangles, indel mutations.
