Extended Data Fig. 1: Phylogenetic relationship and spike amino acid mutations profiles of different SARS-CoV-2 variants.
From: Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
a, Phylogenetic tree of variants nucleotide spike sequences, rooted on the Wuhan-Hu-1 reference sequence. b, Heatmap showing amino acid mutations and deletions in each spike variant sequence with respect to Wuhan-Hu-1 (yellow = non-polar amino acids, green = polar, orange = acidic, blue = basic, grey = deletion). Variants are ordered based on their nucleotide spike phylogenetic tree shown at the top. The design of the B.1.640 spike was based on the initial genome sequences where the 136-144 deletion was not present in >50% and therefore not included; B.1.640 has since been split into two sub-lineages (.1 and .2).
