Fig. 4: Hierarchical cluster analysis of pseudotype infectivity profiles across cell lines.
From: Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors
Dendrogram of the 82 pseudotypes infecting at least one cell line, built using WPGMA on the Pearson correlation distance matrix derived from the infectivity correlation matrix between pairs of pseudotypes shown in Supplementary Fig. 21. Shades above branches indicate clusters of pseudotypes formed exclusively by members of the same viral family. Numbers in nodes indicate approximately unbiased bootstrap values >50%. The viral family of each virus and its tropism towards neuroectoderm-derived cells (also shown in Extended Data Fig. 3) are displayed. This tropism was calculated as the difference between the average log2(R + 1) values obtained in neuroectoderm-derived versus all other cell lines. The names of known viral receptors are shown in parentheses (see Fig. 5 for a more complete list). The red rectangle on the right highlights a cluster of RBPs showing a significantly higher preference towards neuroectoderm-derived cells (two-sided Wilcoxon rank-sum test, P < 0.0001).
