Fig. 5: Functional differences between co-excluders and co-colonizers.
From: Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations
a, Distribution of Shannon diversity values obtained among co-excluders (n = 129) and co-colonizers (n = 116), which did not belong to the Enterobacteriaceae family, based on the pattern of KOs detected per genome. Exact P values were calculated with a two-sided Wilcoxon rank-sum test. b, COG functional categories significantly associated with co-colonizers (positive effect size) or co-excluders (negative effect size). c, Primary metabolic pathways detected with gutSMASH differentially abundant between co-excluders and co-colonizers. d, Pairwise metabolic distances between co-excluders or co-colonizers compared to all Enterobacteriaceae species detected at >1% prevalence (co-excluders: n = 4,773 comparisons; co-colonizers: n = 4,292 comparisons). P values were calculated with a two-sided Wilcoxon rank-sum test. In a and d, box lengths represent the IQR of the data, the central line represents the median, and the whiskers depict the lowest and highest values within 1.5× the IQR of the first and third quartiles, respectively.
