Extended Data Fig. 6: Proteomic comparison of rGlyP and CBB cycle strains.
From: One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle
Global changes in the proteomes of (a) CRG4 and (b) CRG6 compared to the CBB cycle strain and of CRG6 to CRG4 (c). Log2-fold changes in protein intensity are plotted against significance (-log 10 q-Values). Relevant proteins are labeled, shown as a filled-out circles and colored according to their metabolic task. rGlyP proteins associated with module 1 are shown in blue, module 2 in green and module 3 in purple. CBB cycle and hydrogen utilization proteome are depicted in black and brown respectively. Different formate utilization proteins are highlighted in orange. Loci hit by transposon insertions and the frequently observed mutations as in H16_A0258 are shown in turquois. The most up and downregulated proteins if not already categorized, are colored in grey. All other proteins are not labeled, depicted as empty squares and colored grey.
