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Microbiome

Decoding microbe–diet–host synergy in colorectal cancer

A low-carbohydrate diet or host mismatch-repair deficiency promotes colorectal cancer in synergy with colibactin-producing Escherichia coli, while soluble fibre supplements counteract these effects.

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Fig. 1: Dietary fibre deficiency fuels pks+ E. coli colonization and genotoxicity in a mouse model of CRC.

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Correspondence to Thomas F. Meyer.

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Quevedo-Olmos, A., Wang, S. & Meyer, T.F. Decoding microbe–diet–host synergy in colorectal cancer. Nat Microbiol 10, 819–820 (2025). https://doi.org/10.1038/s41564-025-01971-3

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