Extended Data Fig. 3: P. faecium exerts metabolic benefits by polarizing M2 macrophages.
(a) Body weight gain (g), (b) weight (g) of epididymal white adipose tissue (eWAT), (c) blood glucose levels after an oral load of glucose (2 g/kg) and (d) area under the curve (AUC) at week 10 of intervention. (e) ratio of M1 to M2 macrophages (f) mRNA relative expression of indicated genes in the small intestine, (g) fasting glycemia (mg/dL), (h) mean relative abundance by group of the 15 most abundant genera/families, (i) Beta-diversity based on weighted UniFrac distances. Values are presented as mean (Control, HFHSD and HFHSD + P. faecium n = 8; HFHSD + P. faecium + GW2580 and HFHSD + GW2580 n = 7) ± s.e.m. Data points show measurement s from each individual mouse sample. Significant differences were assessed by one- or two-way ANOVA. Differential abundance analysis was performed using the DESeq2 v.1.36R package. Asterisk (*) represent statistical significance at *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
