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The T-series bacteriophages are reductionist models that continue to shape the field

Jeremy Barr discusses how he began studying bacteriophages, the historic use of the T-series phages and how they have shaped the field.

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Fig. 1: A scanning electron microscopy image of the bacterium E. coli B being parasitized by the virulent T4 bacteriophage.

References

  1. Barr, J. J., Slater, F. R., Fukushima, T. & Bond, P. L. FEMS Microbiol. Ecol. 74, 631–642 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. D’Herelles, F. C. R. Acad. Sci. 165, 373–375 (1917).

    Google Scholar 

  3. Twort, F. W. Lancet 186, 1241–1243 (1915).

    Article  Google Scholar 

  4. Luria, S. E. & Delbrück, M. Genetics 28, 491–511 (1943).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hershey, A. D. & Chase, M. J. Gen. Physiol. 36, 39–56 (1952).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ellis, E. L. & Delbrück, M. J. Gen. Physiol. 22, 365–384 (1939).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Abedon, S. T. Genetics 155, 481–486 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Barr, J. J. et al. Proc. Natl Acad. Sci. USA 110, 10771–10776 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Subedi, D. & Barr, J. J. mSystems 6, e00990–20 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rohwer, F. & Segall, A. M. Nature 528, 46–47 (2015).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Jeremy J. Barr.

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Barr, J.J. The T-series bacteriophages are reductionist models that continue to shape the field. Nat Microbiol 10, 1028–1029 (2025). https://doi.org/10.1038/s41564-025-01990-0

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