Extended Data Fig. 4: Summary of structural modelling of WonAB and related systems.
From: West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems
(a–e) Cartoon representations coloured by chain showing the AlphaFold3 predicted structures for WonAB, and the related OLD-ABC ATPase + Novel REase and PD-T4-4 systems. The ATPase components WonA, OLD-ABC ATPase and PD-T4-4_A were modelled as a monomer (a) and a dimer (b), and further modelled as a complex with either one (c) or two (d) copies of the nuclease components WonB, Novel REase and PD-T4-4_B. (e) Nuclease components modelled alone, highlighting the location of the predicted PD-(D/E)xK nuclease residues. The predicted template modelling (pTM) score, and where appropriate, the interface predicted template modelling (ipTM) score, are shown alongside each model. Protein sequences were obtained from NCBI: V. cholerae A1552 WonA (AWB73975.1) and WonB (AWB73976.1); Anaerovibrio lipolyticus DSM 3074 OLD-ABC ATPase (SHI83489.1) + Novel REase (SHI83462.1); E. coli MOD1-ECOR58 PD-T4-4_A (RCO57999.1) and PD-T4-4_B (RCO57988.1).
