Extended Data Fig. 7: Target peptides of FIKK1, FIKK9.1, or FIKK12 modelled into the substrate-binding groove of the FIKK AlphaFold structures (see Methods).
From: The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound
Peptides may correspond to a likely target peptide of the kinase, or idealised targets based on the results of the OPAL arrays. FIKK kinase domain coloured according to the residues pLDDT score and the substrate peptide is coloured in green. Negatively charged amino acids are labelled in red, positively charged amino acids are labelled in blue, hydrophobic amino acids are labelled in brown.
